Perinatal Growth Disturbance in the Spontaneously Hypertensive Rat
| Autor: | N. S. Bassett, B M Johnston, Rohan M. Lewis, Stephen J. M. Skinner, David C Batchelor, James Napier |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Gestational Age Placental insufficiency Hematocrit Essential hypertension Rats Inbred WKY Spontaneously hypertensive rat Insulin-Like Growth Factor II Rats Inbred SHR Internal medicine Genetic model medicine Animals Humans cardiovascular diseases Insulin-Like Growth Factor I Fetus Fetal Growth Retardation medicine.diagnostic_test business.industry Body Weight Metabolic disorder Organ Size medicine.disease Placentation Rats Insulin-Like Growth Factor Binding Proteins Disease Models Animal Endocrinology Animals Newborn Liver Hypertension embryonic structures Pediatrics Perinatology and Child Health cardiovascular system Gestation Female business circulatory and respiratory physiology |
| Zdroj: | Pediatric Research. 42:758-764 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Disproportionate fetal and placental growth are associated with the development of hypertension in the rat and human. Here we report differences in fetal, neonatal, and placental growth, and in metabolism and endocrinology, between the spontaneously hypertensive rat (SHR), a genetic model for human essential hypertension, and the control Wistar-Kyoto (WKY) strain. Gestation in SHR (23 d) was longer than in WKY by 20 h. Body weights were lower in the SHR from fetal d 16 to 20 and on postnatal d 15. However, on fetal d 22 and postnatal d 1, there was no significant difference in body weight between SHR and WKY. SHR placentas were larger than those of WKY at d 20, and by term there was a difference of 30% (p < 0.01). Other indices of disproportionate growth were hypertrophy of the fetal heart and kidney and decreased ponderal index in the SHR neonate. Blood glucose in SHR fetuses was lower than in WKY fetuses (p < 0.05), whereas blood lactate was higher (p < 0.05) and fetal hematocrit was reduced (p< 0.001). These findings suggest undernutrition and placental insufficiency may occur in SHR fetuses. Plasma IGF-II was increased on the last day of gestation in both strains, whereas IGF-I was unaltered. Fetal liver IGFBP-2 mRNA and plasma IGFBP-2 levels were reduced in SHR on fetal d 20 and 22(p < 0.01). Differences in growth and endocrine and metabolic parameters suggest abnormal perinatal physiology in the SHR, which may influence the later development of hypertension. |
| Databáze: | OpenAIRE |
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