Syntheses, Antifeedant Activity, and QSAR Analysis of New Oxa(thia)diazolyl 3(2H)-Pyridazinones
| Autor: | Qingchun Huang, Na Wei, Song Cao, Chuanmeng Zhao, Lina Li, Xuhong Qian |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Insecticides
Oxadiazoles Quantitative structure–activity relationship Chemical Phenomena Chemistry Physical Stereochemistry Chemistry Quantitative Structure-Activity Relationship General Chemistry Moths Pyridazines Eating Molar refractivity Thiadiazoles Partial least squares regression Animals General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry. 53:3120-3125 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | Twenty-eight new oxa(thia)diazolyl 3(2H)-pyridazinone derivatives were synthesized. Some compounds showed good chronic growth activities against the armyworm, Pseudaletia separata (Walker). Their EC50 values were determined in vivo. Nineteen 2-tert-butyl-4-chloro-5-[5'-aryl-2'-(1',3',4'-oxadiazolyl)methoxy]-3(2H)-pyridazinones were quantitatively analyzed using the QSAR procedure. The partial least squares method was applied to find relationships between activity and the physicochemical data. The results showed that dipole moment, molar refractivity, and log P are identified as critical parameters for chronic growth effects. |
| Databáze: | OpenAIRE |
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