Serum triple-marker screening in in vitro fertilization and naturally conceived pregnancies
| Autor: | Jacob A. Canick, Richard J. Hackett, Leonard H. Kellner, Devereux N. Saller, Joseph W. Hogan, Gary N. Frishman |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Down syndrome medicine.medical_specialty medicine.medical_treatment Population Aneuploidy Fertilization in Vitro Chorionic Gonadotropin Pregnancy Blood plasma medicine Humans Neural Tube Defects education reproductive and urinary physiology Gynecology education.field_of_study In vitro fertilisation Estriol Singleton business.industry Obstetrics Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Gestation Female alpha-Fetoproteins Down Syndrome business Biomarkers |
| Zdroj: | Obstetrics & Gynecology. 90:98-101 |
| ISSN: | 0029-7844 |
| DOI: | 10.1016/s0029-7844(97)00139-7 |
| Popis: | Objective To determine whether results of second-trimester maternal serum triple-marker screening for Down syndrome and open neural tube defects in singleton pregnancies conceived from in vitro fertilization (IVF) differ from those of pregnancies conceived spontaneously. Methods The screen-positive rates and triple-marker levels of patients conceiving singleton pregnancies by IVF were compared to age-adjusted standards. Results Sixty-nine singleton IVF pregnancies with maternal serum screening were identified. Twenty-one (30.4%) of the 69 IVF singleton pregnancies had a positive screen for Down syndrome compared with a 14.4% expected screen-positive rate for the maternal age distribution in our observed sample ( P = .013). The screen-positive rate for open neural tube defects in the measured population was similar to anticipated values based on historic controls (5.8% in IVF patients versus 5.3% in the total population). The median levels of the triple markers were 0.95 multiples of the median (MoM) for alpha-fetoprotein (AFP), 0.90 MoM for unconjugated estriol (E3), and 1.22 MoM for hCG. Conclusion The increased hCG levels as well as the slightly lower AFP and unconjugated E3 levels may contribute to the higher Down syndrome screen-positive rate in this IVF singleton population. These results may be due to the number of embryos transferred, the maternal hormonal environment of the IVF process, or other factors. Pregnancies conceived by IVF may be twice as likely to have a positive maternal serum screening test. As additional data are collected, corrected standards should be determined. |
| Databáze: | OpenAIRE |
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