| Autor: |
L. Nava-Gómez, I. Calero-Vargas, F. Higinio-Rodríguez, B. Vázquez-Prieto, R. Olivares-Moreno, J. Ortiz-Retana, P. Aranda, N. Hernández-Chan, G. Rojas-Piloni, S. Alcauter, M. López-Hidalgo |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
eNeuro. |
| ISSN: |
2373-2822 |
| Popis: |
Brain aging is a natural process that involves structural and functional changes that lead to cognitive decline, even in healthy subjects. This detriment has been associated with NMDA receptor (NMDAR) hypofunction because of a reduction in the brain levels of D-serine, the endogenous NMDAR co-agonist. However, it is not clear whether D-serine supplementation could be used as an intervention to reduce or reverse age-related brain alterations. In the present work, we aimed to analyze the D-serine effect on aging-associated alterations in cellular and large-scale brain systems that could support cognitive flexibility in rats. We found that D-serine supplementation reverts the age-related decline in cognitive flexibility, frontal dendritic spine density, and partially restored large-scale functional connectivity without inducing nephrotoxicity; instead, D-serine restored the thickness of the renal epithelial cells that were affected by age. Our results suggest that D-serine could be used as a therapeutic target to reverse age-related brain alterations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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