Effects of Prazosin on Human Fat-Cell Lipolysis and Adenylate Cyclase Activity In Vitro
| Autor: | Daerr W, Kather H |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Pharmacology
medicine.medical_specialty Chemistry Lipolysis Adenylate kinase Alpha (ethology) Prazosin In vitro Enzyme Activation Catecholamines Endocrinology Adipose Tissue In vivo Internal medicine Adenylyl Cyclase Inhibitors Quinazolines medicine Catecholamine Humans Cardiology and Cardiovascular Medicine Cyclase activity Adenylyl Cyclases medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 4:S248 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-198200042-00013 |
| Popis: | The effects of prazosin on adrenergic-stimulated fat-cell lipolysis and adenylate cyclase activity were investigated. The results revealed that the antilipolytic alpha-adrenergic catecholamine effects on human fat-cell metabolism are mediated via alpha 2-receptor sites displaying extremely low affinity to prazosin, which is alpha 1-site selective. The data provide an explantation for the lack of effect of prazosin on lipid mobilization in vivo. The molecular sites mediating the lipid-lowering action of the drug, however, remain to be elucidated. |
| Databáze: | OpenAIRE |
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