Hemophagocytic syndrome, a diagnostic challenge in Gastroenterology
| Autor: | María Del Mar Martín-Rodríguez, Eduardo Redondo-Cerezo, Rita Jiménez Rosales |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Antibiotics Rectum Adenocarcinoma Malignancy Gastroenterology Lymphohistiocytosis Hemophagocytic Fatal Outcome Rare Diseases Internal medicine Rectal carcinoma medicine Humans Histiocyte Hemophagocytic lymphohistiocytosis Chemotherapy business.industry Rectal Neoplasms General Medicine Middle Aged medicine.disease medicine.anatomical_structure business Infiltration (medical) |
| Popis: | Hemophagocytic lymphohistiocytosis is a syndrome of severe immune activation with macrophage and T- cell infiltration resulting in multi organ damage. We report the case of a patient successfully treated for a haemophagocytic syndrome triggered by a metastatic neoplasm of the rectum. A 57 years old man is initially presented with fever without focus. Despite of wide spectrum antibiotics he developed a multi-organ dysfunction. A bone marrow aspirate showed histiocytes that had phagocytosed hematic cells. Hemophagocytic syndrome was suspected and specific treatment was administered. The patient's condition improved remarkably and he was discharged. Nevertheles, finally, the patient died due to a bad response to chemotherapy. Malignancies are a well known triggering of hemophagocytic lymphohistiocytosis being hematological the most commun malignancy associated. However, solid tumors are anecdotic and, to our knowledge, this case is the first one documented due only to rectal carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|