Redrawing therapeutic boundaries: microbiota and cancer
| Autor: | Jonathan Sholl, Thomas Pradeu, Gregory D. Sepich-Poore, Rob Knight |
|---|---|
| Přispěvatelé: | Immunology from Concept and Experiments to Translation (ImmunoConcept), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), European Project: 637647,H2020,ERC-2014-STG,IDEM(2015), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB) |
| Rok vydání: | 2022 |
| Předmět: |
Network medicine
Cancer Research causality Carcinogenesis [SDV]Life Sciences [q-bio] Oncology and Carcinogenesis [SDV.CAN]Life Sciences [q-bio]/Cancer Bioinformatics medicine.disease_cause digestive system Article [SHS]Humanities and Social Sciences [SHS.HISPHILSO]Humanities and Social Sciences/History Philosophy and Sociology of Sciences 03 medical and health sciences fluids and secretions 0302 clinical medicine Neoplasms medicine cancer 2.1 Biological and endogenous factors Humans Aetiology network medicine 030304 developmental biology Predictive biomarker Clinical Oncology therapeutic modulation 0303 health sciences Bacteria business.industry Microbiota [SHS.PHIL]Humanities and Social Sciences/Philosophy biomarkers Cancer medicine.disease 3. Good health stomatognathic diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Oncology Cancer incidence 030220 oncology & carcinogenesis [SDV.IMM]Life Sciences [q-bio]/Immunology Cancer development business |
| Zdroj: | Trends Cancer Trends in cancer, vol 8, iss 2 Trends in Cancer Trends in Cancer, Cell Press, 2021, ⟨10.1016/j.trecan.2021.10.008⟩ Trends in Cancer, 2022, 8 (2), pp.87-97. ⟨10.1016/j.trecan.2021.10.008⟩ |
| ISSN: | 2405-8033 |
| DOI: | 10.1016/j.trecan.2021.10.008 |
| Popis: | International audience; The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host’s proximal and distal microbiota influence both cancer incidence and therapeutic responsiveness. Continuing the history of cancer–microbe research, these findings raise a key question: to what extent is the microbiota relevant for clinical oncology? We approach this by critically evaluating three issues: how the microbiota provides a predictive biomarker of cancer growth and therapeutic responsiveness, the microbiota’s causal role(s) in cancer development, and how therapeutic manipulations of the microbiota improve patient outcomes in cancer. Clarifying the conceptual and empirical aspects of the cancer-associated microbiota can orient future research and guide its implementation in clinical oncology. |
| Databáze: | OpenAIRE |
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