Comparative Study of the Hepatoprotective Efficacy of Artemisia iwayomogi and Artemisia capillaris on Ethanol-Administered Mice
| Autor: | Mi-Kyung Lee, Myung-Joo Kim, Kyeong Won Yun, Hae-In Lee, Kyung-Ok Seo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
Aspartate transaminase Pharmacology Antioxidants Phosphatidate Mice chemistry.chemical_compound Lactate dehydrogenase medicine Animals Aspartate Aminotransferases Carnitine Triglycerides Hypolipidemic Agents Mice Inbred ICR Carnitine O-Palmitoyltransferase Ethanol L-Lactate Dehydrogenase biology Triglyceride Plant Extracts Chemistry Cholesterol Acetaldehyde CYP2E1 Glutathione Artemisia Liver Biochemistry biology.protein Chemical and Drug Induced Liver Injury Biomarkers Food Science medicine.drug |
| Zdroj: | Journal of Food Science. 76:T207-T211 |
| ISSN: | 0022-1147 |
| DOI: | 10.1111/j.1750-3841.2011.02385.x |
| Popis: | We compared the effects of ethylacetate extracts from Artemisia iwayomogi (AIE) and Artemisia capillaris (ACE) on ethanol-induced hepatic injury in mice. Ethanol (25% v/v, 5 g/kg body weight) was orally administered once a day for 6 wk. AIE or ACE was provided in the diet (0.05 g/100 g diet). AIE and ACE did not affect hepatic alcohol dehydrogenase activity but did significantly inhibit cytochrome P450 2E1 activity. Hepatic acetaldehyde dehydrogenase 2 activity significantly increased in the AIE group compared to the control group. AIE caused a significant decrease in plasma acetaldehyde levels and aspartate transaminase and lactate dehydrogenase activities, whereas ACE slightly decreased these values compared to the control. Hepatic catalase activity and glutathione levels were significantly increased by AIE and ACE supplements, whereas glutathione peroxidase activity was higher only in the AIE group compared to the control group. AIE and ACE supplements significantly lowered the plasma cholesterol concentration and increased the HDL-cholesterol/total cholesterol ratio compared to the control group. Compared to the control, both AIE and ACE groups showed a significant decrease in hepatic triglyceride levels and an increase in fecal triglyceride excretion simultaneous with inhibition hepatic activities of fatty acid synthase, phosphatidate phosphohyrolase, fatty acid β-oxidation, and carnitine palmitoyltransferase. AIE significantly lowered hepatic cholesterol levels and increased fecal cholesterol levels compared to the control. These results indicate that AIE and ACE exhibit hepatoprotective and hypolipidemic properties by enhancing hepatic alcohol, antioxidant, and lipid metabolism. AIE seemed to have more potent hepatoprotective effects than ACE. |
| Databáze: | OpenAIRE |
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