G protein-coupled receptors function as cell membrane receptors for the steroid hormone 20-hydroxyecdysone
| Autor: | Zhao, Xiao-Fan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Insecta Steroid hormone medicine.medical_treatment lcsh:Medicine Estrogen receptor Review Biochemistry Receptors G-Protein-Coupled Cell membrane 03 medical and health sciences GPCR 0302 clinical medicine medicine Animals Humans lcsh:QH573-671 Receptor Cell membrane receptor Molecular Biology G protein-coupled receptor lcsh:Cytology Chemistry Endoplasmic reticulum Cell Membrane lcsh:R Cell Biology Hormones Cell biology Ecdysterone 030104 developmental biology medicine.anatomical_structure Insect Hormones Signal pathway 20-hydroxyecdysone Signal transduction hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Signal Transduction Hormone |
| Zdroj: | Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-9 (2020) Cell Communication and Signaling : CCS |
| ISSN: | 1478-811X |
| DOI: | 10.1186/s12964-020-00620-y |
| Popis: | Abstract G protein-coupled receptors (GPCRs) are cell membrane receptors for various ligands. Recent studies have suggested that GPCRs transmit animal steroid hormone signals. Certain GPCRs have been shown to bind steroid hormones, for example, G protein-coupled estrogen receptor 1 (GPER1) binds estrogen in humans, and Drosophila dopamine/ecdysteroid receptor (DopEcR) binds the molting hormone 20-hydroxyecdysone (20E) in insects. This review summarizes the research progress on GPCRs as animal steroid hormone cell membrane receptors, including the nuclear and cell membrane receptors of steroid hormones in mammals and insects, the 20E signaling cascade via GPCRs, termination of 20E signaling, and the relationship between genomic action and the nongenomic action of 20E. Studies indicate that 20E induces a signal via GPCRs to regulate rapid cellular responses, including rapid Ca2+ release from the endoplasmic reticulum and influx from the extracellular medium, as well as rapid protein phosphorylation and subcellular translocation. 20E via the GPCR/Ca2+/PKC/signaling axis and the GPCR/cAMP/PKA-signaling axis regulates gene transcription by adjusting transcription complex formation and DNA binding activity. GPCRs can bind 20E in the cell membrane and after being isolated, suggesting GPCRs as cell membrane receptors of 20E. This review deepens our understanding of GPCRs as steroid hormone cell membrane receptors and the GPCR-mediated signaling pathway of 20E (20E-GPCR pathway), which will promote further study of steroid hormone signaling via GPCRs, and presents GPCRs as targets to explore new pharmaceutical materials to treat steroid hormone-related diseases or control pest insects. Graphical abstract |
| Databáze: | OpenAIRE |
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