Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts
| Autor: | Marc A. Taylor, Gregory W. Barsness, E. Magnus Ohman, Elliot Schechter, Nancy M. Wildermann, Michael J. Miller, Christopher E. Buller, Carl L. Tommaso, Lisa G. Berdan, A.Bleakley Chandler, David Hasdai, Jim T. Smith, David R. Holmes, Anthony L. Pucillo, Jonathan S. Reiner, David Churchill, Mark Gonzalez |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Percutaneous medicine.medical_treatment Abciximab Premedication Pilot Projects Platelet Glycoprotein GPIIb-IIIa Complex Coronary Angiography Veins Immunoglobulin Fab Fragments Angioplasty Internal medicine medicine Humans cardiovascular diseases Myocardial infarction Thrombus Angioplasty Balloon Coronary Coronary Artery Bypass Infusion Pumps Aged business.industry Coronary Thrombosis Graft Occlusion Vascular Antibodies Monoclonal Thrombolysis Middle Aged medicine.disease Surgery Stenosis Treatment Outcome Cardiology Female Stents Cardiology and Cardiovascular Medicine business TIMI Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | American heart journal. 139(5) |
| ISSN: | 0002-8703 |
| Popis: | Background Existing thrombus can complicate percutaneous saphenous vein graft (SVG) intervention. Local delivery of thrombolytics has been used to reduce the thrombus burden often associated with these interventions. We sought to determine whether local delivery of a platelet glycoprotein IIb/IIIa inhibitor is feasible and can reduce thrombus burden before percutaneous SVG intervention. Methods We performed a multicenter pilot study of abciximab (0.25 mg/kg) given by local delivery catheter before percutaneous intervention for de novo SVG stenoses followed by intravenous infusion. All patients (n = 58) had ≥60% stenosis and Thrombolysis In Myocardial Infarction (TIMI) grade >0 flow in an SVG of 3 to 4 mm in diameter. Percent diameter stenosis, TIMI thrombus grade, and TIMI flow grade were measured before and after delivery of abciximab and after intervention. Results Median percent diameter stenosis improved from 69% to 45% ( P = .0001) after local delivery, and TIMI thrombus grade ≥1 incidence reduced from 68% to 34% ( P = .0001). TIMI flow grade was not significantly affected ( P = .12). All patients had a successful intervention (≤50% residual stenosis). Conclusions Local abciximab delivery before percutaneous SVG intervention is associated with significantly reduced thrombus burden, significantly improved percent diameter stenosis, and excellent acute procedural results. Further studies of this approach are warranted to define its clinical utility. |
| Databáze: | OpenAIRE |
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