Circulating expression levels of CircHIPK3 and CDR1as circular-RNAs in type 2 diabetes patients
| Autor: | Bahman Khalvati, Gholamabbas Sabz, Farzaneh Rezaeinejad, Behnam Alipoor, Ali Mirzaei |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Type 2 diabetes Sensitivity and Specificity Spearman's rank correlation coefficient Diagnosis Differential Prediabetic State Correlation Pathogenesis Internal medicine Genetics medicine Humans Molecular Biology Aged business.industry Type 2 Diabetes Mellitus RNA Circular General Medicine Middle Aged medicine.disease Control subjects Peripheral blood Up-Regulation Blood pressure Endocrinology Diabetes Mellitus Type 2 ROC Curve Case-Control Studies Female RNA Long Noncoding business |
| Zdroj: | Molecular Biology Reports. 49:131-138 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | Recent investigations suggested that deregulated levels of Circular RNAs (circRNAs) could be associated with type 2 diabetes mellitus (T2DM) pathogenesis. Accordingly, this study aimed to determine the expression levels of circulating CircHIPK3, CDR1as and their correlation with biochemical parameters in patients with T2DM, pre-diabetes and control subjects. The expression of circRNAs in peripheral blood was determined using QRT-PCR in 70 patients with T2DM, 60 pre-diabetes and in 69 age and sex matched healthy controls. Moreover, bioinformatics tools were applied to explore and predict the potential interactions between circRNAs and other non-coding RNAs (ncRNAs). Our analysis revealed that the expression level of CircHIPK3 was significantly elevated in T2DM patients compared to healthy participants (P |
| Databáze: | OpenAIRE |
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