A Case of Histiocytic Sarcoma Diagnosed by Bone Marrow Biopsy in a Patient Suffering from Fever for 8 Months
| Autor: | Seongsoo Jang, Yun Ha Jang, Hyun Sook Chi, Chan-Jeong Park, Joo Ryong Huh |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Fever Clinical Biochemistry Antigens Differentiation Myelomonocytic Histiocytic sarcoma Antigen Antigens CD Bone Marrow Biopsy medicine Humans Histiocyte medicine.diagnostic_test CD68 business.industry S100 Proteins Biochemistry (medical) General Medicine Middle Aged medicine.disease Epithelium Platelet Endothelial Cell Adhesion Molecule-1 medicine.anatomical_structure Immunohistochemistry Muramidase Histiocytic Sarcoma Bone marrow Tomography X-Ray Computed business |
| Zdroj: | Annals of Laboratory Medicine. 29:282-285 |
| ISSN: | 2234-3814 2234-3806 |
| DOI: | 10.3343/kjlm.2009.29.4.282 |
| Popis: | Histiocytic sarcoma is a malignant proliferation of cells showing morphologic and immunophenotypic features similar to those of mature tissue histiocytes and is known for its rapid progression and poor prognosis. We describe a case of histiocytic sarcoma diagnosed by bone marrow biopsy. A 64-yr-old male was admitted for fever and weight loss that persisted for 8 months. The patient died undiagnosed on the 7th hospitalization day. A bone marrow biopsy performed just before the patient's death revealed diffuse proliferation of large pleomorphic neoplastic cells with large, round to oval nuclei, vesicular chromatin, and abundant foamy cytoplasm. These cells were positive for histiocytic markers, CD68, lysozyme, CD21, and S-100 protein, but negative for B-cell, T/NK-cell, and epithelial cell markers, thus confirming the presence of histiocytic sarcoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|