Three-year clinical outcome using the Contura multilumen balloon breast brachytherapy catheter to deliver accelerated partial breast irradiation (APBI): Improving radiation standards for the optimal application of APBI
| Autor: | D. Keith Pope, Angela B. Robbins, Paulomi Shroff, Philip Z. Israel, Sheree Brown, Mark McLaughlin |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Brachytherapy Breast Neoplasms Balloon Catheterization Breast cancer medicine Humans Radiology Nuclear Medicine and imaging Longitudinal Studies Stage (cooking) Aged Retrospective Studies business.industry Balloon catheter Cosmesis Partial Breast Irradiation Equipment Design Middle Aged medicine.disease United States Surgery Equipment Failure Analysis Catheter Treatment Outcome Oncology Seroma Practice Guidelines as Topic Female Radiology business |
| Zdroj: | Brachytherapy. 11:316-321 |
| ISSN: | 1538-4721 |
| Popis: | Purpose We reviewed our institution’s 3-year clinical experience in treating patients with the Contura multilumen balloon (SenoRx, Inc., Aliso Viejo, CA) breast brachytherapy catheter to deliver accelerated partial breast irradiation (APBI). Methods and Materials Forty-six patients treated with breast-conserving therapy received adjuvant radiation using the Contura catheter (34 Gy in 3.4 Gy fractions). Fourteen patients had Stage 0, 24 had Stage I, and 8 had Stage II breast cancer. Median follow-up was 36 months (range, 1–44 months). Results Only one local recurrence developed (2%). The rate of persistent seroma formation at latest reported follow-up was 4.3% (2 patients) and the incidence of any clinically detectable telengiectasias was 2.2%. No major toxicities (0% Grade III) have occurred. The median skin dose (% of the prescribed dose) was 99.7. The median dose to 95% of the planning target volume for evaluation was 98.8%. The percentage of patients with excellent/good cosmetic results at 24 (n = 23) and 36 (n = 22) months was 100% and 97%, respectively. Conclusion Adjuvant APBI using the Contura multilumen balloon catheter exhibited similar locoregional control, cosmesis, and toxicities to other forms of APBI with similar lengths of follow-up. In addition, improved radiation standards for the delivery of APBI were demonstrated. |
| Databáze: | OpenAIRE |
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