A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands
| Autor: | Esther Sanchez Aliaga, Marc H. A. Jansen, Gertjan J.L. Kaspers, W. Peter Vandertop, Dannis G. van Vuurden, Sophie E. M. Veldhuijzen van Zanten |
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| Přispěvatelé: | Pediatric surgery, Radiology and nuclear medicine, Neurosurgery, CCA - Innovative therapy |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Population Cohort Studies Pons medicine International literature Overall survival Brain Stem Neoplasms Humans Pharmacology (medical) education Child High-Grade Glioma Netherlands Retrospective Studies education.field_of_study business.industry Incidence (epidemiology) Retrospective cohort study Glioma Prognosis Clinical trial Survival Rate Clinical research Oncology Child Preschool Physical therapy Female business |
| Zdroj: | Expert Review of Anticancer Therapy, 15(2), 157-64. Taylor and Francis Ltd. Veldhuijzen van Zanten, S E M, Jansen, M H A, Sanchez Aliaga, E, van Vuurden, D G, Vandertop, W P & Kaspers, G J L 2015, ' A twenty-year review of diagnosing and treating children with diffuse intrinsic pontine glioma in The Netherlands ', Expert Review of Anticancer Therapy, vol. 15, no. 2, pp. 157-64 . https://doi.org/10.1586/14737140.2015.974563 |
| ISSN: | 1473-7140 |
| DOI: | 10.1586/14737140.2015.974563 |
| Popis: | INTRODUCTION: Children with diffuse intrinsic pontine glioma (DIPG) face a dismal prognosis, with a median overall survival of 9 months. Our aims are to determine the incidence of DIPG in the Netherlands and to identify points for improvement in clinical research, a prerequisite for increasing the chance to find a cure.METHODS: We performed a population-based retrospective cohort study by evaluating all children diagnosed with DIPG in the Netherlands between 1990 and 2010.RESULTS: The incidence of DIPG in the Netherlands corresponds with international literature. Between 1990 and 2010, a large heterogeneity of treatment schedules was applied and only a minority of patients was included in clinical trials.DISCUSSION: Given the rarity of DIPG, we emphasize the need for (inter-)national trials to facilitate the identification of potentially effective therapeutics in the future. This can be supported by the recent development of a European DIPG registry enabling international study collaborations. |
| Databáze: | OpenAIRE |
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