Efficacy and safety of the metformin-mazindol anorectic combination in rat
| Autor: | Francisco J. Flores-Murrieta, Geovanna Nalley Quiñonez-Bastidas, Juan Carlos Huerta-Cruz, Federico Argüelles-Tello, Juan Gerardo Reyes-García, José Eduardo Roa-Coria, Ángel Zúñiga-Romero, Héctor I. Rocha-González |
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| Rok vydání: | 2020 |
| Předmět: |
mazindol-metformin combination
Male Diabetes risk endocrine system diseases medicine.drug_class Pharmaceutical Science Administration Oral 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Pharmacology Anxiolytic hypoglycemic effect anxiolysis 03 medical and health sciences 0302 clinical medicine Oral administration Appetite Depressants medicine Animals Hypoglycemic Agents Rats Wistar Maze Learning anorectic interaction Pharmaceutical industry Mazindol Dose-Response Relationship Drug business.industry digestive oral and skin physiology nutritional and metabolic diseases General Medicine Effective dose (pharmacology) Metformin Rats Blood chemistry Anorectic Drug Therapy Combination HD9665-9675 business medicine.drug |
| Zdroj: | Acta Pharmaceutica, Vol 71, Iss 2, Pp 279-291 (2021) Acta Pharmaceutica Volume 71 Issue 2 |
| ISSN: | 1846-9558 1330-0075 |
| Popis: | The current study investigates the anorectic interaction and safety of the mazindol-metformin combination in rats. Isobologram and interaction index were used to determine anorectic interaction between mazindol and metformin in the sweetened milk model. The safety profile of the mazindol-metformin combination was determined by measuring anxiety, blood pressure, hematic biometry and blood chemistry. An acute dose of mazindol and metformin administered per os, individually or as a mixture, has reduced the milk consumption in rats in a dose-dependent manner. Theoretical effective dose 40 (ED 40t) did not differ from the experimental effective dose 40 (ED 40e) obtained with the mazindol-metformin mixture in the anorexia experiments, by Student′s t-test. In addition, the interaction index confirmed the additive anorectic effect between both drugs. A single oral dose of ED 40e mazindol-metformin mixture induced anxiolysis in the elevated plus-maze test. Moreover, oral administration of mazindol-metformin combination for 3 months significantly decreased glycemia, but not blood pressure nor other parameters of hematic biometry and blood chemistry. Results suggest that mazindol-metformin combination exerts an additive anorectic effect, as well as anxiolytic and hypoglycemic properties. Mazindol-metformin combination might be useful in obese patients with anxiety disorders or diabetes risk factors. |
| Databáze: | OpenAIRE |
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