Association of D2 dopamine receptor and alcohol dehydrogenase 2 genes with Polynesian alcoholics
| Autor: | A. Elbaz, Terry Ritchie, X. Zhang, M. L. Fourcade-Amadéo, Jacques Mallet, Ernest P. Noble, P.V. Martin, X. Deparis, L. Nicolás, Stéphane Amadéo, M. F. Brugiroux, C. Tetaria |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty Aldehyde dehydrogenase Gene Expression Genetic determinism Polynesia 03 medical and health sciences 0302 clinical medicine Internal medicine Genotype medicine Humans Allele Allele frequency Alleles Genetic association Alcohol dehydrogenase Genetics biology Receptors Dopamine D2 Alcohol Dehydrogenase 030227 psychiatry Psychiatry and Mental health Alcoholism Endocrinology biology.protein Female 030217 neurology & neurosurgery Negroid |
| Zdroj: | European psychiatry : the journal of the Association of European Psychiatrists. 15(2) |
| ISSN: | 0924-9338 |
| Popis: | SummaryAlleles of the D2 dopamine receptor (DRD2) and the alcohol dehydrogenase 2 (ADH2) genes were determined in 69 French Polynesian alcoholic patients and 57 controls matched for racial origin. Three racial groups were studied: pure Polynesians (PP), Polynesians mixed with Caucasian (PCA) ancestry and Polynesians mixed with Chinese (PCH) ancestry. DRD2 A1 allele frequencies in the alcoholics compared to their controls in these groups were: PP,.26 vs .32 (P= .69); PCA, .44 vs .35 (P= .46); PCH, .40 vs 0.39 (P= .88). ADH2 1 allele frequencies in alcoholics compared to their controls groups were: PP, .56 vs .62 (P= .66); PCA, .75 vs .56 (P= .09); PCH, .78 vs .32 (P= .009). In the PCA group, the combination of the DRD2 A1 genotypes and the ADH2 1 homozygotes was strongly associated with alcoholism (P= .0027). This preliminary study shows the importance of ascertaining racial ancestry in molecular genetic association studies. Moreover, it suggests that a combination of genes are involved in susceptibility to the development of alcoholism. |
| Databáze: | OpenAIRE |
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