Proximal Motor Neuropathy, Dermato-Endocrine Syndrome, and IgGk Paraproteinemia
| Autor: | Samuel F. Berkovic, Roger K. Woodruff, John D. Scarlett, Graeme R. Symington, Xenia Dennett |
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| Rok vydání: | 1986 |
| Předmět: |
Male
Melphalan medicine.medical_specialty Paraproteinemia Paraproteinemias Endocrine Syndrome Endocrine System Diseases Skin Diseases Gastroenterology Immunoglobulin kappa-Chains Polyneuropathies Japan Arts and Humanities (miscellaneous) immune system diseases hemic and lymphatic diseases Internal medicine Immunopathology medicine Humans cardiovascular diseases Motor Neurons business.industry Neuromuscular Diseases Syndrome Monoclonal paraproteinemia Middle Aged medicine.disease Surgery Prednisolone Neurology (clinical) business Motor neuropathy medicine.drug |
| Zdroj: | Archives of Neurology. 43:845-848 |
| ISSN: | 0003-9942 |
| DOI: | 10.1001/archneur.1986.00520080083031 |
| Popis: | The association of monoclonal paraproteinemia, neuropathy, and dermato-endocrine disturbances is well recognized in Japan, and it also occurs in white patients. Neuropathy in such patients is classically distal and sensorimotor, and the paraprotein almost always contains lambda light chains. A 58-year-old white man presented with severe progressive proximal motor neuropathy, dermato-endocrine changes, and an IgG kappa paraprotein. Over a 2 1/2-year period, treatment with melphalan and prednisolone produced improvement in the neuropathy and resolution of dermato-endocrine features with a corresponding decline in the serum paraprotein concentration. Subsequent reappearance of the paraprotein, despite treatment, was associated with clinical relapse. |
| Databáze: | OpenAIRE |
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