HIV-1 Genetic Diversity and Transmitted Drug Resistance Among Recently Infected Individuals at Men Who Have Sex with Men Sentinel Surveillance Points in Hebei Province, China
| Autor: | Xianjiang Kang, Hongru Zhao, Yuqi Zhang, Yongjian Liu, Jingyun Li, Xianfeng Wang, Ze Cui, Xinli Lu, Cuiying Zhao, Suliang Chen |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male China Pol genes Adolescent Genotype Molecular Sequence Data Immunology Human immunodeficiency virus (HIV) HIV Infections Drug resistance Biology medicine.disease_cause gag Gene Products Human Immunodeficiency Virus Men who have sex with men Young Adult Virology Drug Resistance Viral medicine Humans Homosexuality Male Recombination Genetic Molecular Epidemiology Genetic diversity Plasma samples Phylogenetic tree env Gene Products Human Immunodeficiency Virus Genetic Variation virus diseases Sequence Analysis DNA Middle Aged Infectious Diseases pol Gene Products Human Immunodeficiency Virus HIV-1 Sentinel Surveillance |
| Zdroj: | AIDS Research and Human Retroviruses. 31:1038-1045 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2015.0160 |
| Popis: | For this study, 50 HIV-1 plasma samples of recently infected men who have sex with men (MSM) were amplified and sequenced. Multiple subtypes were identified by phylogenetic analyses of HIV-1 gag, env, and pol gene regions, including CRF01_AE (56.0%), CRF07_BC (30.0%), subtype B (12.0%), and unique recombinant forms (URFs, 6.0%). CRF01_AE was the most frequent genotype in the epidemic. Three recombination patterns of URFs were identified: 01BC, 01B, and 01C. The rate of HIV-1 transmitted drug resistance (TDR) mutation (M46L) was 2.08% (1/48). URFs and TDR first identified in this study suggest that HIV-1 prevalence is more and more complicated, and HIV-1 drug-resistant strains have begun to spread among at risk populations in Hebei. Our findings can provide vital information for an efficient surveillance system and strategic HIV prevention and control measures in China by revealing the evolutionary status and HIV-1 TDR of HIV-1 strains among recently infected MSM in Hebei Province. |
| Databáze: | OpenAIRE |
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