Next-generation sequencing in schizophrenia and other neuropsychiatric disorders
| Autor: | Debby W. Tsuang, Matthew Schreiber, Michael Dorschner |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Genetics
medicine.medical_specialty Models Genetic business.industry Public health Schizophrenia (object-oriented programming) Inheritance Patterns High-Throughput Nucleotide Sequencing Disease medicine.disease DNA sequencing Cellular and Molecular Neuroscience Psychiatry and Mental health Psychotic Disorders medicine Schizophrenia Autism Humans Psychiatry business Genetics (clinical) Genome-Wide Association Study |
| Zdroj: | American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. (7) |
| ISSN: | 1552-485X |
| Popis: | Schizophrenia is a debilitating lifelong illness that lacks a cure and poses a worldwide public health burden. The disease is characterized by a heterogeneous clinical and genetic presentation that complicates research efforts to identify causative genetic variations. This review examines the potential of current findings in schizophrenia and in other related neuropsychiatric disorders for application in next-generation technologies, particularly whole-exome sequencing (WES) and whole-genome sequencing (WGS). These approaches may lead to the discovery of underlying genetic factors for schizophrenia and may thereby identify and target novel therapeutic targets for this devastating disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text