Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii in New Caledonia

Autor: Flore Lacassin, Francine Baumann, Virginie Falcot, S. Le Hello, Patrice Nordmann, Thierry Naas
Přispěvatelé: Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur (RIIP), Centre hospitalier territorial Gaston-Bourret [Nouméa], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Résistances émergentes aux antibiotiques, Institut National de la Santé et de la Recherche Médicale (INSERM), This work was funded by the French government through the Ministère de l'Outre-Mer (no. 05 T5) and the Ministère de l'Education Nationale et de la Recherche (UPRES-EA3539), and by the European Community (6th PCRD, LSHM-CT-2005-018705).
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Acinetobacter baumannii
MESH: beta-Lactamases
Drug resistance
Polymerase Chain Reaction
law.invention
MESH: Carbapenems
MESH: Genotype
carbapenemase
0302 clinical medicine
law
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Genotype
MESH: DNA Fingerprinting
Cluster Analysis
030212 general & internal medicine
MESH: Bacterial Proteins
Polymerase chain reaction
Antibacterial agent
0303 health sciences
Molecular Epidemiology
hospital cohort
General Medicine
Anti-Bacterial Agents
Electrophoresis
Gel
Pulsed-Field
Infectious Diseases
MESH: Electrophoresis
Gel
Pulsed-Field
DNA profiling
Conjugation
Genetic
MESH: Isoelectric Focusing
Neisseriaceae
MESH: Acinetobacter Infections
Acinetobacter Infections
DNA
Bacterial
Microbiology (medical)
Biology
beta-Lactamases
Microbiology
03 medical and health sciences
Bacterial Proteins
New Caledonia
MESH: Anti-Bacterial Agents
Drug Resistance
Bacterial
MESH: Drug Resistance
Bacterial
Humans
MESH: Molecular Epidemiology
MESH: Humans
Molecular epidemiology
OXA-23
030306 microbiology
MESH: Acinetobacter baumannii
MESH: Conjugation
Genetic
MESH: Polymerase Chain Reaction
biology.organism_classification
MESH: New Caledonia
DNA Fingerprinting
MESH: Cluster Analysis
MESH: DNA
Bacterial
Carbapenems
Isoelectric Focusing
Zdroj: Clinical Microbiology and Infection
Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2008, 14 (10), pp.977-981. ⟨10.1111/j.1469-0691.2008.02068.x⟩
ISSN: 1198-743X
1469-0691
DOI: 10.1111/j.1469-0691.2008.02068.x⟩
Popis: International audience; Carbapenem-resistant Acinetobacter baumannii (CR-Ab) ranked third, with a frequency of 24.8%, among 202 strains of multidrug-resistant bacteria isolated from clinical samples in the main hospital of New Caledonia in 2004. All CR-Ab isolates were analysed by isoelectric focusing, conjugation, pulsed-field gel electrophoresis and PCR for the presence of carbapenemase genes. Fifty CR-Ab isolates produced carbapenemase OXA-23. The isolates belonged to a single clone presenting several subtypes, suggesting an endemic situation. This study further illustrates the widespread prevalence of carbapenemase OXA-23-producing CR-Ab isolates in the South Pacific.
Databáze: OpenAIRE
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