Reactivity to a 35% CO2 challenge in healthy first-degree relatives of patients with panic disorder

Autor: Nicole van Beek, Eric Griez
Rok vydání: 2000
Předmět:
Zdroj: Biological psychiatry. 47(9)
ISSN: 0006-3223
Popis: Background: The effects of a 35% CO 2 challenge were examined in healthy first-degree relatives of panic disorder patients and in healthy control subjects matched for age and gender. Methods: One single inhalation of a 35% CO 2 /65% O 2 challenge was administered to 50 first-degree relatives of panic disorder patients and 50 control subjects. Results: The first-degree relatives were more reactive to the 35% CO 2 challenge than the control subjects. Conclusions: These findings indicate that being a member of a family with a panic disorder patient is, in itself, an important factor in CO 2 hypersensitivity among subjects who have never experienced a panic attack. Both panic disorder patients and their first-degree relatives have a tendency to be more reactive to the CO 2 challenge.
Databáze: OpenAIRE