Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
| Autor: | Jean-Yves Hogrel, Gillian Butler-Browne, Liam Bagley, Steven Bradburn, Nasser Al-Shanti, Chris Murgatroyd, David M. A. Mann, Neil Pendleton, Marco Narici, Mati Pääsuke, Andrew C Robinson, Yoann Barnouin, Michael C. Carroll, Antony Payton, Helena Gapeyeva, Sarianna Sipilä, Mark Slevin, Jamie S. McPhee, Andrea B. Maier |
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| Přispěvatelé: | Manchester Metropolitan University (MMU), Università degli Studi di Camerino = University of Camerino (UNICAM), Institut de Myologie, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), University of Tartu, University of Melbourne, University of Jyväskylä (JYU), University of Nottingham, UK (UON), University of Manchester [Manchester], University of Camerino, Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Association française contre les myopathies (AFM-Téléthon)-Sorbonne Université (SU), Gestionnaire, HAL Sorbonne Université 5, Centre de Recherche en Myologie, Internal medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
gamma interferon inducible protein 10 genomic DNA Alzheimerin tauti Epigenesis Genetic Cohort Studies CXCL10 gene Cognition single nucleotide polymorphism cognitive defect Cognitive decline Aged 80 and over Cerebral Cortex education.field_of_study prefrontal cortex DNA methylation General Neuroscience adult Neurodegeneration neurodegeneration ta3141 U937 Cells Methylation ta3142 Alzheimer's disease cohort analysis DNA-metylaatio aged female priority journal epigenetiikka Alzheimer disease transcription regulation Alzheimer’s disease kognitiiviset taidot medicine.medical_specialty [SDV.MHEP.AHA] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] in vitro study Adolescent heredity Population Biology Article working memory Young Adult 03 medical and health sciences Cognitive aging promoter region male Memory Internal medicine Journal Article medicine [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO] Humans CXCL10 controlled study Epigenetics human brain level education epigenetics cognitive aging human cell aging disease association medicine.disease major clinical study Inflammaging Chemokine CXCL10 genomic DNA adult age CpG island inflammation 030104 developmental biology Endocrinology ikääntyminen Nerve Degeneration inflammaging Neurology (clinical) Geriatrics and Gerontology HeLa Cells Developmental Biology |
| Zdroj: | Neurobiology of Aging Neurobiology of Aging, 2017, 63, pp.54-64. ⟨10.1016/j.neurobiolaging.2017.11.009⟩ Bradburn, S, McPhee, J, Bagley, L, Carroll, M, Slevin, M, Al-Shanti, N, Barnouin, Y, Hogrel, J-Y, Pääsuke, M, Gapeyeva, H, Maier, A, Sipilä, S, Narici, M, Robinson, A, Mann, D, Payton, A, Pendleton, N, Butler-Browne, G & Murgatroyd, C 2018, ' Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance ', Neurobiology of Aging, vol. 63, pp. 54-64 . https://doi.org/10.1016/j.neurobiolaging.2017.11.009 Neurobiology of Aging, Elsevier, 2017, 63, pp.54-64. ⟨10.1016/j.neurobiolaging.2017.11.009⟩ Neurobiology of Aging, 63, 54-64. Elsevier Inc. |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.11.009 |
| Popis: | International audience; Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorphism (rs56061981) that altered methylation at one of these CpG sites further associated with working memory performance in 2 independent aging cohorts. Studying prefrontal cortex samples, we found higher CXCL10 protein levels in those with Alzheimer's disease, compared with aged controls. These findings support the association of peripheral inflammation, as demonstrated by CXCL10, in aging and cognitive decline. We reveal age-related epigenetic and genetic factors which contribute to the dysregulation of CXCL10. |
| Databáze: | OpenAIRE |
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