Antimicrobial resistance comparison of Klebsiella pneumoniae pathogens isolated from intra-abdominal and urinary tract infections in different organs, hospital departments and regions of China between 2014 and 2017

Autor: Qiwen Yang, Jingjia Zhang, Yingchun Xu, Ge Zhang, Simeng Duan, Yang Yang, Dongxue Li, Hui Zhang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Microbiology (medical)
China
medicine.medical_specialty
Imipenem
medicine.drug_class
Klebsiella pneumoniae
Antibiotic resistance
Cefepime
030106 microbiology
Antibiotics
Hospital Departments
Microbial Sensitivity Tests
Microbiology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Intra-abdominal infections
Drug Resistance
Bacterial
medicine
polycyclic compounds
Humans
Immunology and Allergy
030212 general & internal medicine
Cross Infection
General Immunology and Microbiology
biology
business.industry
General Medicine
Antimicrobial
biology.organism_classification
bacterial infections and mycoses
Urinary tract infections
female genital diseases and pregnancy complications
QR1-502
Klebsiella Infections
Community-Acquired Infections
Infectious Diseases
chemistry
Carbapenems
ESBL
Amikacin
Intraabdominal Infections
business
Ertapenem
medicine.drug
Zdroj: Journal of Microbiology, Immunology and Infection, Vol 54, Iss 4, Pp 639-648 (2021)
ISSN: 1684-1182
Popis: Background We describe antibiotic resistance trends of Klebsiella pneumoniae pathogens, responsible for urinary tract infections (UTIs) and intra-abdominal infections (IAIs), isolated from different organs and tissues, hospital departments and Chinese regions between 2014 and 2017. Methods Resistances of UTIs and IAIs derived K. pneumoniae isolates from 17 hospitals in 7 Chinese regions to amikacin, imipenem, piperacillin-tazobactam, ertapenem, and cefepime were unequivocally established. Results Overall resistance rates of K. pneumoniae IAI isolates obtained from gallbladder and abscesses increased to amikacin (14.29–30.95%) and for liver, gallbladder, and abscesses to imipenem (14.29–38.10%), piperacillin-tazobactam (23.81–38.10%), and ertapenem (23.81–38.10%) in 2017, but were constant (20–30%) for K. pneumoniae isolates from UTIs from 2014 to 2017. In medical and surgical ICUs, resistance rates to all tested antibiotics rose to ∼60% for IAIs, which was also reflected in higher resistance rates of hospital acquired (HA) compared to community acquired (CA) infections. In medical ICUs resistance rates increased to 50–60% for amikacin, imipenem, and ertapenem for UTI-derived K. pneumoniae isolates in 2017. Resistance rates to all tested antibiotics were highest in the east Jiangzhe region of China, being ∼60% for K. pneumoniae isolates from IAIs and 40% for K. pneumoniae isolates from UTIs to ertapenem and imipenem, as well as > 40% for piperacillin-tazobactam in 2017. Conclusion In China, ICUs resistance rates to K. pneumoniae IAIs and UTIs isolates was increased in 2017 for all tested antimicrobials including carbapenems, which makes them no longer suitable for empiric treatment. In the east Jiangzhe region this was a general trend that was independent of the type of hospital department.
Databáze: OpenAIRE
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