Pulmonary nodules: differential diagnosis using 18F-fluorodeoxyglucose single-photon emission computed tomography
| Autor: | M J Adam, Anna Celler, P Champion, D B Coupland, Nestor L. Müller, K G Evans, Richard J. Finley, J S Kwong, D. Lyster, D F Worsley |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Fluorine Radioisotopes Lung Neoplasms Radiography Single-photon emission computed tomography Deoxyglucose Sensitivity and Specificity Diagnosis Differential Fluorodeoxyglucose F18 Spect imaging medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Lung Fluorodeoxyglucose Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Solitary Pulmonary Nodule Nodule (medicine) General Medicine Middle Aged Feasibility Studies Female Radiology Tomography Differential diagnosis medicine.symptom Nuclear medicine business Emission computed tomography medicine.drug |
| Zdroj: | AJR. American journal of roentgenology. 168(3) |
| ISSN: | 0361-803X |
| Popis: | The objective of this study was to prospectively evaluate the feasibility and efficacy of single-photon emission computed tomography (SPECT) with 18F-fluorodeoxyglucose (FDG) for differentiating malignant from benign pulmonary nodules.Twenty-six patients with 28 radiologically indeterminate focal pulmonary lesions were examined. Fasting patients were injected with 5 MBq/kg of FDG (maximum dose, 370 MBq). Imaging was performed with dual-head SPECT cameras equipped with 511-keV collimators.Seventeen of 21 pathologically malignant nodules showed FDG uptake on SPECT imaging (sensitivity, 81%). None of the seven benign modules showed uptake (specificity, 100%). SPECT imaging with FDG was positive in all 16 malignant nodules that were larger than or equal to 2 cm in diameter. However, only one (20%) of five nodules smaller than 2 cm in diameter showed positive on SPECT imaging.Using current technology, we found FDG SPECT imaging useful for distinguishing benign from malignant pulmonary nodules that were larger than or equal to 2 cm in diameter. However, because of the relatively low sensitivity of SPECT, smaller malignant nodules were not adequately revealed. |
| Databáze: | OpenAIRE |
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