Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy
| Autor: | Keizo Kagawa, Toshiaki Sakai, Tasuku Hara, Takashi Okuda, Tomoya Ohara, Kohei Oka, Junichi Sakagami, Naoto Iwai, Toshiyuki Komaki, Toshifumi Tsuji, Masashi Taniguchi |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Radiofrequency ablation Interferon therapy Case Report RC799-869 Gastroenterology law.invention Virological response 03 medical and health sciences 0302 clinical medicine Chronic hepatitis Fibrosis law Interferon Internal medicine Histological diagnosis medicine business.industry virus diseases General Medicine Diseases of the digestive system. Gastroenterology medicine.disease digestive system diseases 030220 oncology & carcinogenesis Hepatocellular carcinoma 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | Case Reports in Hepatology, Vol 2020 (2020) Case Reports in Hepatology |
| ISSN: | 2090-6595 2090-6587 |
| DOI: | 10.1155/2020/8824974 |
| Popis: | A 77-year-old man with chronic hepatitis C (CH-C) infection, who achieved a sustained virological response (SVR) to interferon (IFN) therapy, was followed up regularly. Before IFN therapy, he did not have metabolic diseases, and the histological diagnosis of his chronic hepatitis was stage-3 fibrosis. After achieving SVR, the fibrosis-4 (FIB-4) index level dropped once but gradually increased. 21 years after SVR, hepatocellular carcinoma (HCC) was diagnosed by dynamic computed tomography. The HCC was 12 mm in diameter. The HCC was treated with radiofrequency ablation. CH-C patients with advanced fibrosis require long-term follow-up, even after achieving SVR. |
| Databáze: | OpenAIRE |
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