Six-month follow-up study of health markers of nanomaterials among workers handling engineered nanomaterials
| Autor: | Chiou-Jong Chen, Hui-Ling Lee, Chin-Chi Lin, Hung-Che Chiang, Wei-Te Wu, Tsui-Chun Tsou, Lih-Ann Li, Jin-Huei Hsu, Saou-Hsing Liou, Tung-Sheng Shih, Jiune-Jye Ho, Ching-Huang Lai, Yu-Teh Chung, Wan-Fen Li, Ming-Hsiu Lin, Hui-Yi Liao, Shu-Li Wang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pathology
medicine.medical_specialty Antioxidant medicine.medical_treatment Biomedical Engineering Taiwan Physiology Inflammation Toxicology medicine.disease_cause Pulmonary function testing Superoxide dismutase Occupational Exposure medicine Humans chemistry.chemical_classification biology business.industry Glutathione peroxidase Paraoxonase Nanostructures chemistry biology.protein medicine.symptom business Oxidative stress Genotoxicity Follow-Up Studies |
| Zdroj: | Nanotoxicology. 8 |
| ISSN: | 1743-5404 |
| Popis: | The aim of this study was to identify the health hazards and possible exposure surveillance markers of workers exposed to nanoparticles during manufacturing and application in comparison to a group of unexposed workers. For this longitudinal study, we recruited 158 nanomaterial-handling workers and 104 non-exposed workers from 14 manufacturing plants in Taiwan (baseline). Among them, 124 nanomaterial-handling workers and 77 unexposed workers were monitored 6 months later. We investigated pulmonary and cardiovascular disease markers, inflammation and oxidative stress markers, antioxidant enzymes and genotoxicity markers. Antioxidant enzymes (superoxide dismutase, glutathione peroxidase) and cardiovascular markers (vascular cell adhesion molecule, paraoxonase) were significantly associated with nanomaterial-handling during the 6-month follow-up period. In addition, the small airway damage marker (Clara cell protein 16) and lung function test parameters were also significantly associated with handling nanomaterials. The study markers and lung function tests are possible markers that could be useful for surveillance of nanomaterial-handling workers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|