Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding
| Autor: | David M. Ornitz, Phillip D. Holler, Oh Sang Kwon, Zhikun Zhang, George Cotsarelis, Maksim V. Plikus, Arben Nace, Sarah E. Millar, Xiaohong Zhang, Mayumi Ito, Sheena Baratono, Fen Wang, Michelle Spata, Chang D Kim, Elsa Treffeisen, Zaixin Yang |
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| Rok vydání: | 2013 |
| Předmět: |
Fibroblast Growth Factor 9
medicine.medical_specialty T-Lymphocytes Population Mice Transgenic Models Biological Article General Biochemistry Genetics and Molecular Biology Neogenesis Mice Dermis Internal medicine medicine Animals Humans Regeneration education Cells Cultured Feedback Physiological Wound Healing education.field_of_study integumentary system biology Regeneration (biology) Wnt signaling pathway General Medicine biology.organism_classification Hair follicle medicine.disease Cell biology Mice Inbred C57BL Wnt Proteins stomatognathic diseases medicine.anatomical_structure Hair loss Endocrinology Wound healing Hair Follicle |
| Zdroj: | Nature Medicine. 19:916-923 |
| ISSN: | 1546-170X 1078-8956 |
| Popis: | Understanding molecular mechanisms for regeneration of hair follicles provides new opportunities for developing treatments for hair loss and other skin disorders. Here we show that fibroblast growth factor 9 (Fgf9), initially secreted by γδ T cells, modulates hair follicle regeneration after wounding the skin of adult mice. Reducing Fgf9 expression decreases this wound-induced hair neogenesis (WIHN). Conversely, overexpression of Fgf9 results in a two- to threefold increase in the number of neogenic hair follicles. We found that Fgf9 from γδ T cells triggers Wnt expression and subsequent Wnt activation in wound fibroblasts. Through a unique feedback mechanism, activated fibroblasts then express Fgf9, thus amplifying Wnt activity throughout the wound dermis during a crucial phase of skin regeneration. Notably, humans lack a robust population of resident dermal γδ T cells, potentially explaining their inability to regenerate hair after wounding. These findings highlight the essential relationship between the immune system and tissue regeneration. The importance of Fgf9 in hair follicle regeneration suggests that it could be used therapeutically in humans. |
| Databáze: | OpenAIRE |
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