Pudendal Nerve Block by Low-Frequency (≤1 kHz) Biphasic Electrical Stimulation
| Autor: | Natalie Pace, Jicheng Wang, Wenbin Guo, Bing Shen, Jonathan M. Beckel, William C. de Groat, Katherine Shapiro, Changfeng Tai, Kody Armann |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Contraction (grammar) Pudendal nerve Neural Conduction Axonal conduction Stimulation Low frequency Article 03 medical and health sciences 0302 clinical medicine Urethra medicine Animals business.industry Urethral sphincter Nerve Block General Medicine Electric Stimulation Pudendal Nerve Anesthesiology and Pain Medicine medicine.anatomical_structure Neurology Cats Neurology (clinical) Nerve conduction business 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Neuromodulation |
| ISSN: | 1525-1403 |
| Popis: | OBJECTIVES To test the hypothesis that poststimulation block of nerve conduction can be achieved by low-frequency (≤1 kHz) biphasic stimulation (LFBS). MATERIALS AND METHODS A tripolar cuff electrode was placed around the pudendal nerve in cats to deliver LFBS (1 kHz, 500 Hz, and 100 Hz). Two bipolar hook electrodes were placed central and distal to the cuff electrode to induce external urethral sphincter (EUS) contractions. A catheter was inserted into the urethra to record EUS contraction pressure. Pudendal nerve block by LFBS was confirmed by the failure of the central hook electrode stimulation to induce EUS contractions, while the distal hook electrode stimulation still induced contractions. RESULTS Pudendal nerve conduction was completely blocked by LFBS at different frequencies (1 kHz, 500 Hz, and 100 Hz) after terminating LFBS. The post-LFBS block induced at the minimal stimulation intensity and duration was fully reversible within the same time period (10-15 min on average) for the three frequencies. However, the stimulation duration to induce block significantly (p |
| Databáze: | OpenAIRE |
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