Cholinergic blockade inhibits gastro-oesophageal reflux and transient lower oesophageal sphincter relaxation through a central mechanism
| Autor: | J Liu, John C. Fang, Ravinder K. Mittal, Y. Yamamoto, I Sarosiek |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Atropine Male medicine.medical_specialty Manometry medicine.drug_class Muscle Relaxation medicine.medical_treatment Methscopolamine Bromide Gastroenterology Parasympatholytic Cholinergic Antagonists Esophagus Bolus (medicine) Internal medicine Gastro-Oesophageal Reflux Pressure medicine Anticholinergic Humans Saline business.industry Reflux Parasympatholytics Hydrogen-Ion Concentration Middle Aged N-Methylscopolamine Muscle relaxation Anesthesia Gastroesophageal Reflux Female Peristalsis Esophagogastric Junction business medicine.drug |
| Zdroj: | Gut. 44:603-607 |
| ISSN: | 1468-3288 0017-5749 |
| Popis: | BACKGROUNDAtropine, an anticholinergic agent with central and peripheral actions, reduces gastro-oesophageal reflux (GOR) in normal subjects and patients with gastro-oesophageal reflux disease (GORD) by inhibiting the frequency of transient lower oesophageal sphincter relaxation (TLOSR).AIMSTo compare the effect of methscopolamine bromide (MSB), a peripherally acting anticholinergic agent, with atropine on the rate and mechanism of GOR in patients with GORD.METHODSOesophageal motility and pH were recorded for 120 minutes in 10 patients with GORD who were studied on three separate occasions. For the first two recording periods, either atropine (15 μg/kg bolus, 4 μg/kg/h infusion) or saline were infused intravenously. MSB (5 mg orally, four times daily) was given for three days prior to the third recording period.RESULTSAtropine significantly reduced basal LOS pressure (12.6 (0.17) mm Hg to 7.9 (0.17) mm Hg), and the number of TLOSR (8.1 (0.56) to 2.8 (0.55)) and reflux episodes (7.0 (0.63) to 2.0 (0.43)) (p0.05).CONCLUSIONIn contrast to atropine, MSB has no effect on the rate of TLOSR or GOR in patients with GORD. Atropine induced inhibition of TLOSR and GOR is most likely mediated through a central cholinergic blockade. |
| Databáze: | OpenAIRE |
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