Analysis of the Effect of Memantine in Reducing the Worsening of Clinical Symptoms in Patients with Moderate to Severe Alzheimer’s Disease
| Autor: | David Wilkinson, Henning Friis Andersen |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience Population Disease Neuropsychological Tests Placebo Central nervous system disease Disability Evaluation Double-Blind Method Alzheimer Disease Memantine Internal medicine Activities of Daily Living medicine Humans Dementia Psychiatry education Nootropic Agents Aged Randomized Controlled Trials as Topic Aged 80 and over education.field_of_study Cognitive disorder medicine.disease Psychiatry and Mental health Disease Progression Female Geriatrics and Gerontology Alzheimer's disease Mental Status Schedule Psychology Excitatory Amino Acid Antagonists medicine.drug |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 24:138-145 |
| ISSN: | 1421-9824 1420-8008 |
| Popis: | Background: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and delaying disease worsening is a relevant treatment outcome. Methods: Data from 6 randomized, double-blind, placebo-controlled, 6-month studies were pooled and a subgroup of patients (867 on placebo, 959 on memantine) with moderate to severe AD (Mini- Mental State Examination Results: More placebo-treated than memantine-treated patients showed any clinical worsening (28 vs. 18%; p < 0.001), and 21% placebo-treated patients compared to 11% memantine-treated patients had marked clinical worsening (p < 0.001). Conclusion: In this population of moderate and severe AD patients, treatment with memantine was associated with reducing worsening of clinical symptoms in AD during the 6-month study period. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|