Error-Speed Correlations in Biopolymer Synthesis

Autor: Yuhai Tu, Simone Pigolotti, Davide Chiuchiu
Rok vydání: 2019
Předmět:
Quantitative Biology - Subcellular Processes
DNA biosynthesis
Molecular Networks (q-bio.MN)
Biophysics
FOS: Physical sciences
General Physics and Astronomy
Thermal fluctuations
Word error rate
engineering.material
Models
Biological
01 natural sciences
Article
Quantitative Biology::Subcellular Processes
Reaction rate
chemistry.chemical_compound
Biopolymers
0103 physical sciences
Humans
Quantitative Biology - Molecular Networks
010306 general physics
Subcellular Processes (q-bio.SC)
Condensed Matter - Statistical Mechanics
Physics
chemistry.chemical_classification
Quantitative Biology::Biomolecules
Statistical Mechanics (cond-mat.stat-mech)
DNA
Polymer
Enzymes
Monomer
Models
Chemical
chemistry
FOS: Biological sciences
Biophysical Process
engineering
RNA
Biopolymer
Biological system
RNA biosynthesis
Zdroj: Phys Rev Lett
ISSN: 1079-7114
0031-9007
DOI: 10.1103/physrevlett.123.038101
Popis: Synthesis of biopolymers such as DNA, RNA, and proteins are biophysical processes aided by enzymes. Performance of these enzymes is usually characterized in terms of their average error rate and speed. However, because of thermal fluctuations in these single-molecule processes, both error and speed are inherently stochastic quantities. In this paper, we study fluctuations of error and speed in biopolymer synthesis and show that they are in general correlated. This means that, under equal conditions, polymers that are synthesized faster due to a fluctuation tend to have either better or worse errors than the average. The error-correction mechanism implemented by the enzyme determines which of the two cases holds. For example, discrimination in the forward reaction rates tends to grant smaller errors to polymers with faster synthesis. The opposite occurs for discrimination in monomer rejection rates. Our results provide an experimentally feasible way to identify error-correction mechanisms by measuring the error-speed correlations.
PDF file consist of the main text (pages 1 to 5) and the supplementary material (pages 6 to 12). Overall, 7 figures split between main text and SI
Databáze: OpenAIRE
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