Atherogenesis takes place in cholesterol-fed rabbits when circulating concentrations of endogenous cortisol are increased and inflammation suppressed
| Autor: | Lisardo Boscá, Teresa Pérez de Prada, Pablo González, Panayotis Fantidis, Marie Anne Pounchard, Aranzazu Ortega Pozzi, Monica Torres Coronado |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Time Factors Hydrocortisone medicine.medical_treatment Hypercholesterolemia Interleukin-1beta Inflammation Endogeny Aorta Thoracic Biology Cholesterol Dietary chemistry.chemical_compound Internal medicine medicine Animals Cholesterol Atherosclerosis Circadian Rhythm Steroid hormone Disease Models Animal Endocrinology Hypercortisolemia chemistry Rabbits medicine.symptom Cardiology and Cardiovascular Medicine Glucocorticoid medicine.drug Lipoprotein Foam Cells |
| Zdroj: | Atherosclerosis. 191(2) |
| ISSN: | 0021-9150 |
| Popis: | Atherosclerosis is an inflammatory disease, but the response of the endogenous anti-inflammatory system during this process has not been evaluated previously. Cortisol is the end product of this anti-inflammatory system, but is also able to activate cellular processes that induce atherogenesis; however, it is unknown whether atherogenesis occurs when circulating concentrations of endogenous cortisol are increased or when they are decreased. We have evaluated the counter-regulatory responses of cortisol and interleukin-1beta (IL-1beta) during the short- and long-term responses to vascular injury in rabbits fed a 2% cholesterol diet. In the short-term group (n=18), serum cortisol and IL-1beta concentrations were measured after 10, 20 and 30 days. Rabbits developed hypercholesterolemia and hypercortisolemia, with only modest increases in IL-1beta. Although inflammation was low-grade, atherogenesis took place, with subintimal lipid accumulation evident on day 30. In the second group (n=18), we evaluated variables after 40, 60 and 90 days. This group developed hypercholesterolemia, but serum cortisol concentrations were inappropriately normal, while IL-1beta concentrations were elevated 8.6-fold; advanced atherosclerotic plaques were evident on days 60 and 90. These results show that atherogenesis occurs when high endogenous cortisol levels are suppressing inflammation, and are consistent with a promotion of early atherogenesis by high cortisol concentrations. |
| Databáze: | OpenAIRE |
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