Erythromycin estolate-induced toxicity in cultured rat hepatocytes
| Autor: | Elsie M. B. Sorensen, Daniel Acosta |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Erythromycin Estolate
Dose-Response Relationship Drug L-Lactate Dehydrogenase Rats Inbred Strains General Medicine Biology Toxicology Ldh release Erythromycin Rats Drug Hypersensitivity Andrology chemistry.chemical_compound Liver Biochemistry chemistry Morphometric analysis Lactate dehydrogenase Toxicity medicine Animals Swelling medicine.symptom Cells Cultured |
| Zdroj: | Toxicology Letters. 27:73-82 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/0378-4274(85)90122-5 |
| Popis: | Primary cultures of rat hepatocytes were exposed to several concentrations of erythromycin estolate (EE). Hepatotoxicity was evaluated using lactate dehydrogenase (LDH) leakage and morphometric analysis of representative populations of cells examined optically. Results of the two techniques provided parallel information: cells exposed to the higher concentrations of EE had significantly greater LDH release and higher percentages of morphologically damaged cells. Planimetrie analysis of a second set of hepatocytes showed increasing swelling of cells with increasing concentration of EE. Severe cellular swelling preceded disintegration, as hepatocytes became progressively more damaged by EE. |
| Databáze: | OpenAIRE |
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