Effect of organised cervical cancer screening on cervical cancer mortality in Europe: a systematic review
| Autor: | Erik E.L. Jansen, Nadine Zielonke, Andrea Gini, Ahti Anttila, Nereo Segnan, Zoltán Vokó, Urška Ivanuš, Martin McKee, Harry J. de Koning, Inge M.C.M. de Kok, Piret Veerus, Sirpa Heinävaara, Tytti Sarkeala, Marcell Csanádi, Janos Pitter, György Széles, Silvia Minozzi, Carlo Senore, Marjolein van Ballegooijen, Inge Driesprong - de Kok, Eveline Heijnsdijk, Erik Jansen, Harry de Koning, Iris Lansdorp – Vogelaar, Nicolien van Ravesteyn, Urska Ivanus, Katja Jarm, Dominika Novak Mlakar, Maja Primic-Žakelj, Jennifer Priaulx |
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| Přispěvatelé: | Public Health |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty MEDLINE Uterine Cervical Neoplasms Cervical cancer screening 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Internal medicine medicine Humans media_common.cataloged_instance Mortality European union Early Detection of Cancer media_common Cervical cancer business.industry Mortality reduction Prognosis medicine.disease 3. Good health Europe Survival Rate 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cohort Inclusion and exclusion criteria Female Observational study business |
| Zdroj: | European Journal of Cancer, 127, 207-223. Elsevier Ltd. European Journal of Cancer |
| ISSN: | 0959-8049 |
| Popis: | Background Organised cervical cancer (CC) screening programmes are delivered in many different ways across the European Union and its regions. Our aim was to systematically review the impact of these programs on CC mortality. Methods Two independent reviewers identified all eligible studies investigating the effect of organised screening on CC mortality in Europe. Six databases including Embase, Medline and Web of Science were searched (March 2018) with predefined inclusion and exclusion criteria. Only original studies with at least five years of follow-up were considered. Validated tools were used to assess the risk of bias of the included studies. Results Ten observational studies were included: seven cohort and three case-control studies. No randomised controlled trials were found, and there were no eligible studies from the eastern and southern part of Europe. Among the eligible studies, seven were conducted in the twentieth century; they scored lower on the risk of bias assessment. CC mortality reduction for women attending organised screening vs. non-attenders ranged from 41% to 92% in seven studies. Reductions were similar in Western (45–92%) and Northern (41–87%) Europe and were higher in the three more recent studies (66–92%). For invited vs. non-invited women, this reduction ranged from 17% to 79% in five studies. Conclusion Although data were lacking in Southern and Eastern Europe and the effect size varied between countries and studies, this systematic review provides evidence that organised CC screening reduces CC mortality in those parts of Europe where CC screening was implemented and monitored. |
| Databáze: | OpenAIRE |
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