Compartmentalized multicellular crosstalk in lymph nodes coordinates the generation of potent cellular and humoral immune responses
| Autor: | Justine Poirot, Coline Trichot, Jasna Medvedovic, Vassili Soumelis |
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| Rok vydání: | 2021 |
| Předmět: |
Immunity
Cellular Stromal cell Immunology Cell Germinal center Cell Communication biochemical phenomena metabolism and nutrition Biology Acquired immune system Immunity Humoral Cell biology Crosstalk (biology) medicine.anatomical_structure Immune system Reticular cell medicine Animals Humans bacteria Immunology and Allergy Compartment (development) Lymph Nodes |
| Zdroj: | European Journal of Immunology. 51:3146-3160 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.202048977 |
| Popis: | Distributed throughout the body, lymph nodes (LNs) constitute an important crossroad where resident and migratory immune cells interact to initiate antigen-specific immune responses supported by a dynamic 3-dimensional network of stromal cells, that is, endothelial cells and fibroblastic reticular cells (FRCs). LNs are organized into four major subanatomically separated compartments: the subcapsular sinus (SSC), the paracortex, the cortex, and the medulla. Each compartment is underpinned by particular FRC subsets that physically support LN architecture and delineate functional immune niches by appropriately providing environmental cues, nutrients, and survival factors to the immune cell subsets they interact with. In this review, we discuss how FRCs drive the structural and functional organization of each compartment to give rise to prosperous interactions and coordinate immune cell activities. We also discuss how reciprocal communication makes FRCs and immune cells perfect compatible partners for the generation of potent cellular and humoral immune responses. |
| Databáze: | OpenAIRE |
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