Neurotrophin blood-based gene expression and social cognition analysis in patients with autism spectrum disorder
| Autor: | Mònica Segura, Alejandro Gella, Regina Taurines, Carla Pedreño, Montserrat Pamias, Jordi E. Obiols, Edna Grünblatt |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Candidate gene Adolescent Autism Spectrum Disorder Theory of Mind Gene Expression Nerve Tissue Proteins Receptors Nerve Growth Factor Tropomyosin receptor kinase B behavioral disciplines and activities Autism Diagnostic Observation Schedule Young Adult Cellular and Molecular Neuroscience Neurotrophin 3 Internal medicine Theory of mind mental disorders Genetics medicine Humans Receptor trkB Nerve Growth Factors RNA Messenger Receptor trkA Child Genetics (clinical) business.industry Brain-Derived Neurotrophic Factor Receptor Protein-Tyrosine Kinases Middle Aged medicine.disease Autism spectrum disorder Endophenotype Biomarker (medicine) Autism Female business Biomarkers |
| Zdroj: | neurogenetics. 16:123-131 |
| ISSN: | 1364-6753 1364-6745 |
| Popis: | Autism spectrum disorders (ASD) comprise neurodevelopmental disorders with clinical onset during the first years of life. The identification of peripheral biomarkers could significantly impact diagnosis and an individualized, early treatment. Although the aetiology of ASD remains poorly understood, there is increasing evidence that neurotrophins and their receptors represent a group of candidate genes for ASD pathophysiology and biomarker research. Total messenger RNA (mRNA) from whole blood was obtained from adolescents and adults diagnosed as ASD (n = 21) according to DSM-IV criteria and confirmed by the Autism Diagnostic Observation Schedule (ADOS) and Autism Diagnostic Interview-Revised (ADI-R) algorithms, as well as healthy controls (n = 10). The mRNA expression of neurotrophins (BDNF, NT3 and NT4) and their receptors (TrkA, TrkB and p75 NTR ) was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Moreover, social cognition abilities of ASD patients and controls were determined according to three Theory of Mind (ToM) tests (Reading the Mind in the Eyes, Faux pas, and Happe stories). The NT3 and NT4 mRNA expression in the whole blood was significantly lower in ASD compared to healthy controls, while p75NTR was higher (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink