Biodegradable vs Nonbiodegradable Cardiac Support Device for Treating Ischemic Cardiomyopathy in a Canine Heart

Autor: Yoshiki Sawa, Ayumi Shintani, Toshiaki Akita, Satsuki Fukushima, Atsuhiro Saito, Shigeru Miyagawa, Mutsunori Kitahara
Rok vydání: 2017
Předmět:
Pulmonary and Respiratory Medicine
Cardiac function curve
medicine.medical_specialty
Time Factors
Myocardial Ischemia
Diastole
030204 cardiovascular system & hematology
Prosthesis Design
Ventricular Function
Left
Prosthesis Implantation
03 medical and health sciences
Dogs
0302 clinical medicine
Internal medicine
Absorbable Implants
Ventricular Pressure
medicine
Animals
Myocardial infarction
Cardiac Surgical Procedures
Ventricular remodeling
Ischemic cardiomyopathy
Ejection fraction
Polyethylene Terephthalates
business.industry
Myocardium
Stroke Volume
Recovery of Function
General Medicine
medicine.disease
Myocardial Contraction
Cardiac support
Biomechanical Phenomena
Disease Models
Animal
Catheter
030228 respiratory system
Ventricular Function
Right
Cardiology
Surgery
Stress
Mechanical
Cardiomyopathies
Cardiology and Cardiovascular Medicine
business
Polyglycolic Acid
Zdroj: Seminars in Thoracic and Cardiovascular Surgery. 29:51-61
ISSN: 1043-0679
Popis: Clinical studies of the efficacy of the nonbiodegradable CorCap device have shown inconsistent findings, at least in part, because of device-related impairment of diastolic cardiac function. We hypothesized that use of biodegradable material for the cardiac support device could contribute to an improvement in the diastolic function of the failing heart. Polyglycolic acid and polyethylene terephthalate were used to prepare biodegradable and nonbiodegradable cardiac support devices, respectively. Twelve-month-old beagles underwent anterior coronary artery ligation. One week after, the beagles were randomly assigned for implantation of a biodegradable cardiac support device (n = 7), nonbiodegradable cardiac support device (n = 8), or sham operation (n = 8). Twelve weeks after coronary artery ligation, the biodegradable group showed a significantly greater recovery of echocardiographical ejection fraction than the nonbiodegradable and the sham groups (40% ± 3.3%, 32% ± 2.5%, and 29 ± 2.6%, respectively). Of note, diastolic function, as assessed by Tau, -dp/dt min, and end-diastolic pressure-volume relationship in the cardiac catheter, was significantly better in both left and right ventricles in the biodegradable group than in the nonbiodegradable group. Moreover, global end-systolic wall stress was significantly lower in the 2 device groups than in the sham group (P 0.03). Furthermore, global end-diastolic wall stress was significantly less in the biodegradable device group than in the nonbiodegradable group (P 0.02). The cardiac support devices made of biodegradable material were more effective in improving systolic function, with preservation of diastolic function in the canine infarct heart, than devices made of nonbiodegradable material.
Databáze: OpenAIRE
Externí odkaz: