One brief exposure to a psychological stressor induces long-lasting, time-dependent sensitization of both the cataleptic and neurochemical responses to haloperidol
| Autor: | Steven Knopf, Anthony R. Caggiula, Donna Kocan, Seymour M. Antelman, David J. Edwards |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Dopamine Nucleus accumbens Catalepsy General Biochemistry Genetics and Molecular Biology Nucleus Accumbens chemistry.chemical_compound Neurochemical Corticosterone Internal medicine Haloperidol medicine Animals General Pharmacology Toxicology and Pharmaceutics Sensitization business.industry Rats Inbred Strains General Medicine medicine.disease Housing Animal Rats medicine.anatomical_structure Endocrinology chemistry Psychological stressor business Stress Psychological medicine.drug |
| Zdroj: | Life sciences. 51(4) |
| ISSN: | 0024-3205 |
| Popis: | Rats were exposed for 10 minutes to one of several enclosures graded in novelty. In one experiment they were then simply sacrificed and plasma corticosterone determinations made in order to obtain an index of the relative stressfulness of these enclosures. In a second experiment the animals received haloperidol and were tested for catalepsy, 2 hours or two weeks following the novel experience. The most novel experience, exposure to a black box, resulted in the highest corticosterone levels and was the only one of our pre-treatments to induce significant enhancement of catalepsy as well as alteration of nucleus accumbens dopamine levels, 2 weeks --but not 2 hours--later. These findings indicate that brief exposure of adult animals to a psychological stressor can induce a long-term alteration in both behavioral and neurochemical responses to a drug and that this effect requires a minimum level of stress to get started and once triggered gets stronger with the passage of time. |
| Databáze: | OpenAIRE |
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