Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1
| Autor: | Sophie Faure, Laurence Meyer, Dominique Costagliola, Céline Vaneensberghe, Emmanuelle Genin, Brigitte Autran, French ALT, IMMUNOCO Study Groups, Jean-François Delfraissy, SEROCO Study Group, David H. McDermott, Philip M. Murphy, Patrice Debré, Ioannis Théodorou, Christophe Combadière |
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| Rok vydání: | 2000 |
| Předmět: |
Chemokine
Genotype Chemokine receptor CCR5 CX3C Chemokine Receptor 1 Single-nucleotide polymorphism HIV Infections Polymorphism Single Nucleotide Virus Linkage Disequilibrium White People Cohort Studies Chemokine receptor Receptors HIV CX3CR1 Humans Receptors Cytokine Polymorphism Single-Stranded Conformational Acquired Immunodeficiency Syndrome Multidisciplinary biology Chemokine CX3CL1 Haplotype Homozygote virus diseases Genetic Variation HIV Membrane Proteins biology.organism_classification Virology Survival Analysis Chemokines CX3C Haplotypes Case-Control Studies Immunology Lentivirus Mutation biology.protein Disease Progression Leukocytes Mononuclear Chromosomes Human Pair 3 Chemokines CXC Polymorphism Restriction Fragment Length |
| Zdroj: | Science (New York, N.Y.). 287(5461) |
| ISSN: | 0036-8075 |
| Popis: | Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor and leukocyte chemotactic/adhesion receptor for the chemokine fractalkine. HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes. Functional CX3CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX3CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS. |
| Databáze: | OpenAIRE |
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