Assessment of the efficacy of a grape seed waste in counteracting the changes induced by aflatoxin B1 contaminated diet on performance, plasma, liver and intestinal tissues of pigs after weaning
| Autor: | C. M. Rotar, Veronica Sanda Chedea, Mihail Alexandru Gras, Ionelia Taranu, Daniela Eliza Marin, Mihai Palade, Gina Cecilia Pistol |
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| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
Aflatoxin Antioxidant Aflatoxin B1 medicine.medical_treatment Sus scrofa Food Contamination Toxicology 01 natural sciences Thiobarbituric Acid Reactive Substances Antioxidants 03 medical and health sciences chemistry.chemical_compound Starter TBARS medicine Weaning Animals Vitis Food science Mycotoxin 0303 health sciences Gastrointestinal tract Meal Chemistry 010604 marine biology & hydrobiology 030302 biochemistry & molecular biology food and beverages Animal Feed Diet Seeds Cytokines Animal Nutritional Physiological Phenomena |
| Zdroj: | Toxicon : official journal of the International Society on Toxinology. 162 |
| ISSN: | 1879-3150 |
| Popis: | The aim of this study was to investigate the potential of a grape seed byproduct to mitigate the harmful damage produced by aflatoxin B1 (AFB1) at systemic level in plasma and liver as well as at local level in the gastrointestinal tract in weaned piglets. Twenty four crossbred pigs (TOPIG) were randomly assigned to one of four experimental diets: 1)- control diet (normal compound feed for starter piglets without mycotoxin), 2)- AFB1 diet (compound feed contaminated with 320 ppb pure AFB1), 3)- GS diet (compound feed including 8% of grape seed meal), 4)- AFB1+GS diet (compound feed containing 8% of grape seed meal contaminated with 320 ppb AFB1) for 30 days. The results showed that pigs fed AFB1 diet had altered performance (−25.1%), increased the thiobarbituric substances (TBARS) concentration wile reduced total antioxidant capacity and activity of antioxidant enzymes (CAT, SOD and GPx) in plasma and organs. AFB1 produced a dual effect on inflammatory response by increasing the level of pro-inflammatory cytokines in liver and colon and decreasing these cytokines in duodenum. The inclusion of grape seed in the diet of AFB1 intoxicated pigs enhanced the antioxidant enzymes activity, decreased the pro-inflammatory cytokines and TBARS level and ameliorated the growth performance of AFB1-treated animals. These findings suggest that grape waste is a promising feed source in counteracting the harmful effect of aflatoxin B1. |
| Databáze: | OpenAIRE |
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