Clinical and structural brain correlates of hypomimia in early‐stage Parkinson's disease

Autor: Sampedro, Frederic, Martínez-Horta, Saul, Horta, Andrea, Grothe, Michael J., Labrador-Espinosa, Miguel A., Jesús, Silvia, Adarmes-Gómez, A. D, Carrillo, Fatima, Puig-Davi, Arnau, Roldan-Lora, Florinda, Aguilar-Barbera, Miquel, Pastor, Pau, Escalante Arroyo, Sonia, Solano Vila, Berta, Cots-Foraster, Anna, Ruiz-Martínez, Javier, Carrillo-Padilla, Francisco, Pueyo-Morlans, Mercedes, Gonzalez-Aramburu, Isabel, Infante-Ceberio, Jon, Hernandez-Vara, Jorge, Fàbregues-Boixar i Nebot, Oriol de, Deus Fonticoba, María Teresa de, Avila, Asuncion, Martínez-Castrillo, Juan Carlos, Bejr-Kasem, Helena, Campolongo, Antonia, Pascual-Sedano, Berta, Martínez-Martín, Pablo, Santos García, Diego, Mir, Pablo, Garcia-Ruiz, Pedro J., Kulisevsky, J., Universitat Autònoma de Barcelona
Přispěvatelé: Curemos el Párkinson
Rok vydání: 2022
Předmět:
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
EUROPEAN JOURNAL OF NEUROLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
ISSN: 1468-1331
1351-5101
DOI: 10.1111/ene.15513
Popis: COPPADIS Study Group.
[Background and purpose] Reduced facial expression of emotions is a very frequent symptom of Parkinson's disease (PD) and has been considered part of the motor features of the disease. However, the neural correlates of hypomimia and the relationship between hypomimia and other non-motor symptoms of PD are poorly understood.
[Methods] The clinical and structural brain correlates of hypomimia were studied. For this purpose, cross-sectional data from the COPPADIS study database were used. Age, disease duration, levodopa equivalent daily dose, Unified Parkinson's Disease Rating Scale part III (UPDRS-III), severity of apathy and depression and global cognitive status were collected. At the imaging level, analyses based on gray matter volume and cortical thickness were used.
[Results] After controlling for multiple confounding variables such as age or disease duration, the severity of hypomimia was shown to be indissociable from the UPDRS-III speech and bradykinesia items and was significantly related to the severity of apathy (β = 0.595; p
[Conclusion] Reduced facial expressivity in PD is related to the severity of symptoms of apathy and is mediated by the dysfunction of brain systems involved in motor control and in the recognition, integration and expression of emotions. Therefore, hypomimia in PD may be conceptualized not exclusively as a motor symptom but as a consequence of a multidimensional deficit leading to a symptom where motor and non-motor aspects converge.
Fundación Curemos el Parkinson (https://curemoselparkinson.org/).
Databáze: OpenAIRE
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