Seroincidence of Human T-Lymphotropic Virus Type I Infection and Characterization of Seroconverters in Jamaican Food Handlers
| Autor: | Paul H. Levine, Barrie Hanchard, Michie Hisada, Paul C. VanVeldhuisen, Michael Walters, Takashi Sawada, Rainford J. Wilks |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Jamaica Adolescent Population Human T-lymphotropic virus Antibodies Viral Serology Cohort Studies Risk Factors Food Industry Humans Medicine Pharmacology (medical) Seroconversion Child education Aged Aged 80 and over Human T-lymphotropic virus 1 education.field_of_study biology business.industry Incidence Incidence (epidemiology) Antibody titer Middle Aged Viral Load Provirus biology.organism_classification HTLV-I Infections Virology Titer Infectious Diseases Immunology Female business Biomarkers |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 33:387-392 |
| ISSN: | 1525-4135 |
| Popis: | Summary: In a prospective study of food handlers in Jamaica, we estimated the age- and sex-specific seroincidence of human T-lymphotropic virus type I (HTLV-I) infection. Of 682 sexually active adults (132 males and 550 females) who were initially seronegative, 12 (1 male and 11 females) seroconverted over 8 years of follow-up. The seroincidence was 1.2 per 1,000 person-years for males and 3.2 per 1,000 person-years for females. The age-standardized incidence was 1.8 times higher for females than for males (P = 0.55). Within a median of 4 years after seroconversion, the median HTLV-I provirus load was 500 copies/105 cells, and the median antibody titer was 1:3109. Four of 12 seroconverters developed antibody to the Tax regulatory protein. HTLV-I infection in this population occurred at a rate comparable with that described for a Japanese cohort. Provirus load, titer and appearance of antibody to the Tax regulatory protein were typical of chronic carriers within a few years of seroconversion. |
| Databáze: | OpenAIRE |
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