Apolipoprotein(a) phenotypes, Lp(a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the apo(a) gene in coronary heart disease
| Autor: | M. C. Tong, Eric Boerwinkle, Nilmani Saha, Ch Sandholzer, Gerd Utermann |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male China medicine.medical_specialty Adolescent Apolipoprotein B Lipoproteins Population Coronary Disease Biology chemistry.chemical_compound Risk Factors Internal medicine Blood plasma medicine Humans Allele education Allele frequency Aged Singapore education.field_of_study Cholesterol Cholesterol HDL Acute-phase protein General Medicine Middle Aged Lipids Apolipoproteins Phenotype Endocrinology chemistry biology.protein Female lipids (amino acids peptides and proteins) Research Article Lipoprotein |
| Zdroj: | Journal of Clinical Investigation. 89:1040-1046 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci115645 |
| Popis: | Elevated lipoprotein(a) (Lp[a]) concentrations are associated with premature coronary heart disease (CHD). In the general population, Lp(a) levels are largely determined by alleles at the hypervariable apolipoprotein(a) (apo[a]) gene locus, but other genetic and environmental factors also affect plasma Lp(a) levels. In addition, Lp(a) has been hypothesized to be an acute phase protein. It is therefore unclear whether the association of Lp(a) concentrations with CHD is primary in nature. We have analyzed apo(a) phenotypes, Lp(a) levels, total cholesterol, and HDL-cholesterol in patients with CHD, and in controls from the general population. Both samples were Chinese individuals residing in Singapore. Lp(a) concentrations were significantly higher in the patients than in the population (mean 20.7 +/- 23.9 mg/dl vs 8.9 +/- 12.9 mg/dl). Apo(a) isoforms associated with high Lp(a) levels (B, S1, S2) were significantly more frequent in the CHD patients than in the population sample (15.9% vs 8.5%, P less than 0.01). Higher Lp(a) concentrations in the patients were in part explained by this difference in apo(a) allele frequencies. Results from stepwise logistic regression analysis indicate that apo(a) type was a significant predictor of CHD, independent of total cholesterol and HDL cholesterol, but not independent of Lp(a) levels. The data demonstrate that alleles at the apo(a) locus determine the risk for CHD through their effects on Lp(a) levels, and firmly establish the role of Lp(a) as a primary genetic risk factor for CHD. |
| Databáze: | OpenAIRE |
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