| Autor: |
Stefan Bentink, Guido Reifenberger, Otmar D. Wiestler, Carlo Schaller, Manuel Montesinos-Rongen, Katia Basso, J. Rubenstein, Martina Deckert, Rainer Spang, Riccardo Dalla-Favera, Anna Brunn, Reiner Siebert, Wolfram Klapper, Wei Keat Lim |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Leukemia, Vol. 22, No 2 (2008) pp. 400-405 |
| ISSN: |
0887-6924 |
| Popis: |
To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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