Feasibility of tomotherapy to reduce cochlea radiation dose in patients with locally advanced nasopharyngeal cancer
| Autor: | Nguyen, Nam P., Misty Ceizyk, Vincent Vinh-Hung, Thomas Sroka, Siyoung Jang, Rihan Khan, Angela Locke, Gabby Albala, Christina Truong, Juan Godinez, Richard Vos, Lexie Smith-Raymond |
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| Přispěvatelé: | Radiation Therapy, Translational Radiation Oncology and Physics, Faculty of Medicine and Pharmacy |
| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research nasopharyngeal cancer cochlea sparing Tomotherapy 03 medical and health sciences 0302 clinical medicine Humans image guided radiation therapy Radiation Injuries 030223 otorhinolaryngology Aged Neoplasm Staging Retrospective Studies Nasopharyngeal Carcinoma Radiotherapy Planning Computer-Assisted Carcinoma Nasopharyngeal Neoplasms Radiotherapy Dosage Chemoradiotherapy General Medicine Middle Aged Radiotherapy Computer-Assisted Cochlea Treatment Outcome Oncology Lymphatic Metastasis 030220 oncology & carcinogenesis Feasibility Studies Female Radiotherapy Intensity-Modulated |
| Zdroj: | Vrije Universiteit Brussel |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089161209800606 |
| Popis: | Aims and background To evaluate the effectiveness of tomotherapy-based image-guided radiotherapy (IGRT) on the radiation dose to the cochlea in patients with nasopharyngeal cancer. Methods and study design A retrospective review of five patients undergoing concurrent chemoradiation with tomotherapy for locally advanced nasopharyngeal cancer was performed. Results The mean dose to the right and left cochlea was 25 Gy and 35.3 Gy respectively, while the dose to the gross tumor ranged from 70 to 75 Gy. All patients had excellent clinical response to the treatment at a median follow-up of five months. Conclusions IGRT for head and neck cancer delivered by tomotherapy can significantly decrease the radiation dose to the cochlea without sacrificing target volume coverage. |
| Databáze: | OpenAIRE |
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