Endocrine Disruptors Induced Distinct Expression of Thyroid and Estrogen Receptors in Rat versus Mouse Primary Cerebellar Cell Cultures

Autor:	Zoltan Barany, Eniko Ioja, István János Tóth, Attila Zsarnovszky, Gergely Jocsak, Laszlo V. Frenyo, Dávid Sándor Kiss, Tibor Bartha
Rok vydání:	2019
Předmět:	medicine.medical_specialty medicine.drug_class Receptor expression Estrogen receptor 010501 environmental sciences Biology 01 natural sciences Article 03 medical and health sciences Internal medicine medicine bisphenol A (BPA) Endocrine system Receptor estrogen receptor α (ERα) and estrogen receptor β (ERβ) Neural cell 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences General Neuroscience Thyroid zearalenone (ZEN) medicine.anatomical_structure Endocrinology Estrogen thyroid receptor α (TRα) and thyroid receptor β (TRβ) primary cerebellar neurons arsenic (As) Hormone
Zdroj:	Brain Sciences Volume 9 Issue 12
ISSN:	2076-3425
DOI:	10.3390/brainsci9120359
Popis:	The endocrine system of animals consists of fine-tuned self-regulating mechanisms that maintain the hormonal and neuronal milieu during tissue development. This complex system can be influenced by endocrine disruptors (ED)&mdash substances that can alter the hormonal regulation even in small concentrations. By now, thousands of substances&mdash either synthesized by the plastic, cosmetic, agricultural, or medical industry or occurring naturally in plants or in polluted groundwater&mdash can act as EDs. Their identification and testing has been a hard-to-solve problem Recent indications that the ED effects may be species-specific just further complicated the determination of biological ED effects. Here we compare the effects of bisphenol-A, zearalenone, and arsenic (well-known EDs) exerted on mouse and rat neural cell cultures by measuring the differences of the ED-affected neural estrogen- and thyroid receptors. EDs alters the receptor expression in a species-like manner detectable in the magnitude as well as in the nature of biological responses. It is concluded that the interspecies differences (or species specificity) in ED effects should be considered in the future testing of ED effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3a3a7d698b3b1e75f0cd70e909df45 https://doi.org/10.3390/brainsci9120359 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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