Surface heparinization of central venous catheters reduces microbial colonization in vitro and in vivo: results from a prospective, randomized trial
| Autor: | Olle Larm, Lars Bindslev, Pia Appelgren, Frank Espersen, Ulrika Ransjö |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Catheterization Central Venous Staphylococcus Bacteremia Critical Care and Intensive Care Medicine Bacterial Adhesion law.invention Catheters Indwelling Double-Blind Method law In vivo medicine Humans Prospective Studies Prospective cohort study Fungemia Aged Aged 80 and over Cross Infection business.industry Heparin Middle Aged medicine.disease Intensive care unit Surgery Catheter Parenteral nutrition Equipment Contamination Female business medicine.drug |
| Zdroj: | Critical care medicine. 24(9) |
| ISSN: | 0090-3493 |
| Popis: | Objective : To evaluate in vitro and in vivo the efficacy of covalent end point-attached heparin to single-lumen polyurethane central venous catheters in reducing microbial adherence and colonization. Design : In vitro study : A controlled bench study. In vivo study : A prospective, randomized, double-blind, clinical trial. Setting : Intensive care unit in a 1200-bed teaching hospital. Interventions : In vitro study : Adhesion of 17 radiolabeled clinical isolates of Staphylococci to catheters was examined in vitro. In vivo study : The outcome of heparinized and control catheters was compared in vivo in patients receiving long-term parenteral nutrition. Fifty-five adult patients were prospectively, blindly randomized to heparinized or control central venous catheters. The catheters, removed on clinical grounds, were analyzed with semiquantitative and quantitative cultures. Blood cultures were done at catheter removal. Measurements and Main Results : In vitro study : Coagulase-negative Staphylococci adhered less in vitro to heparinized catheters than to control catheters (p |
| Databáze: | OpenAIRE |
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