Association of UCP1, UCP2 and UCP3 gene polymorphisms with cardiovascular disease risk factors in European adolescents: the HELENA study
| Autor: | Azahara I. Rupérez, Jonatan R. Ruiz, Diego F Salazar-Tortosa, Ascensión Marcos, Catherine Leclercq, Manuel J. Castillo, Aline Meirhaeghe, Jose M. Pascual-Gamarra, S. Gómez, Idoia Labayen, Luis A. Moreno |
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| Přispěvatelé: | European Commission, Universidad de Granada, Ministerio de Educación, Cultura y Deporte (España), Instituto de Salud Carlos III, Junta de Andalucía |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B biology business.industry Insulin medicine.medical_treatment Haplotype Quantitative insulin sensitivity check index Gastroenterology 03 medical and health sciences 0302 clinical medicine Blood pressure 030225 pediatrics Internal medicine Pediatrics Perinatology and Child Health biology.protein Genetic predisposition Homeostatic model assessment Medicine Allele business 030217 neurology & neurosurgery |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 2005-0070 |
| Popis: | [Background]: Cardiovascular diseases (CVDs) are responsible for 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. The aim of this study was to examine the association of UCP1, UCP2 and UCP3 gene polymorphisms with CVD risk factors in European adolescents. [Method]: A cross-sectional study that involves 1.057 European adolescents (12–18 years old) from the HELENA study. A total of 18 polymorphisms of UCP1, UCP2 and UCP3 genes were genotyped. We measured serum total cholesterol, high-density lipoprotein,low-density lipoprotein, ApoA1, ApoB, leptin, triglycerides, glucose, insulin and blood pressure, and calculated HOMA (homeostatic model assessment), Quantitative Insulin Sensitivity Check Index (QUICKI) and a CVD risk score. [Results]: The G allele of UCP2 rs2735572 and T allele of UCP2 rs17132534 were associated with higher diastolic blood pressure (P = 0.001; false discovery rate [FDR] = 0.009 and P = 8e–04; FDR = 0.009, respectively). We observed that the AATAG haplotype of UCP1 was associated with higher serum ApoB/ApoA1 (P = 0.008; FDR = 0.031) and ApoB levels (P = 0.008; FDR = 0.031). Moreover, the ACC haplotype of UCP3 was associated with a higher CVD risk score (P = 0.0036; FDR = 0.01). [Conclusions]: Two UCP2 polymorphisms and haplotypes of UCP1 and UCP3 were associated with CVD risk factors. These findings suggest that UCPs may have a role in the development of CVD already in adolescents. The HELENA Study is supported by contract FOOD-CT-2005-007034 from the European Community Sixth RTD Framework Programme. The study was supported by the Spanish Ministry of Education (FPU16/02127, FPU13/03410), by the University of Granada Plan Propio de Investigación 2016 (Excellence actions: Unit of Excellence on Exercise and Health [UCEES]), by the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades, by the European Regional Development Fund (ERDF), ref. SOMM17/6107/UGR and by Redes Temáticas de Investigación Cooperativa RETIC grant Red SAMID RD16/0022. |
| Databáze: | OpenAIRE |
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