CHARACTERISTICS OF THE FORMATION AND CONVERSION OF ANDROGENIC HORMONES IN THE RAT ADRENAL GLAND
| Autor: | T. Fehér, Steczek K, O. Koref |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Male
medicine.medical_specialty Rat Adrenal Gland Endocrinology Diabetes and Metabolism Chorionic Gonadotropin Adenosine Triphosphate Endocrinology Adrenocorticotropic Hormone Internal medicine Adrenal Glands medicine Animals Testosterone Isomerases Progesterone Chemistry Hydroxysteroid Dehydrogenases Dehydroepiandrosterone General Medicine Metyrapone Rats Cholesterol Pregnenolone Androgens Gonadotropins Hormone Endocrine gland |
| Zdroj: | Acta Endocrinologica. 66:727-736 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0660727 |
| Popis: | Incubated rat adrenal slices failed to convert cholesterol, pregnenolone and 17-OH-progesterone into C19-steroids under the experimental conditions used. Dehydroepiandrosterone was converted to androstenedione and 11-OH-androstenedione. The formation of androstenedione and 11-OH-androstenedione could also be demonstrated by using testosterone precursor. Corticotrophin in vitro did not affect the rate of conversion and the amount of 11-hydroxylated derivative increased when ATP was also added to the medium. Human chorionic gonadotrophin enhanced 11-hydroxylation in the presence of ATP. Inhibition of 11β-hydroxylase activity by metopirone was not affected by ATP. |
| Databáze: | OpenAIRE |
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