Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage
| Autor: | J Dornand, G. Rondouin, F. de Bock |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Kainic acid medicine.medical_specialty Excitotoxicity Kainate receptor Status epilepticus Biology Hippocampal formation medicine.disease_cause Hippocampus Rats Sprague-Dawley chemistry.chemical_compound Organ Culture Techniques Status Epilepticus Internal medicine medicine Animals Neurons Kainic Acid Microglia Cell Death Interleukin-6 Tumor Necrosis Factor-alpha General Neuroscience Glutamate receptor Amygdala Rats medicine.anatomical_structure Endocrinology nervous system chemistry Immunology Tumor necrosis factor alpha medicine.symptom |
| Zdroj: | Neuroreport. 7(6) |
| ISSN: | 0959-4965 |
| Popis: | We studied the production of tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) 2 and 7 days following status epilepticus (SE), induced in rats by intra-amygdala injection of kainate. At day 2 the release of both cytokines by hippocampal slices prepared from epileptic animals was increased compared to controls, whereas at day 7 only TNF alpha secretion was enhanced. Since SE-induced neuronal damage is probably due to excitotoxicity, we investigated the effects of agonists of glutamate receptors on TNF alpha release in organotypic hippocampal cultures. A correlation was found between the damage intensity and the release of TNF alpha, suggesting production of this cytokine by macrophagic microglia. We propose a role for TNF alpha and IL-6 in the adaptive phenomena which follow severe limbic seizures. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|